Phosgene → 4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride

HRID 645733

反応式

HRID 645733 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[NH:11][C:10]([C:20]3[C:21]([O:29][CH2:30][CH3:31])=[N:22][C:23]([O:26][CH2:27][CH3:28])=[N:24][CH:25]=3)=[N:9]2)=[CH:4][CH:3]=1.[C:32](Cl)([Cl:34])=[O:33]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:32]([Cl:34])=[O:33])[C:10]([C:20]3[C:21]([O:29][CH2:30][CH3:31])=[N:22][C:23]([O:26][CH2:27][CH3:28])=[N:24][CH:25]=3)=[N:9]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 6371PhosgeneHCID 866136274,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-1H-imidazole

生成物 1

HCID 866136264,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride

実験手順

Using the procedure as described in example 1, cis-4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-1H-imidazole was reacted with phosgene to give cis-4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride. The carbonyl chloride was then coupled with 2-piperazinone (Alfa) to give cis-4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one. HR-MS (ES, m/z) calculated for C28H29N6O4Cl2 [(M+H)+] 583.1622, observed 583.1621.

出典と根拠

ORDレコード
ord-7dc1c6474a374b829a2d02cf48a344b4
出典データセット
uspto-grants-2010_04
特許番号
US07705007B2

関連ノート

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