関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-(4-Hydroxyphenoxy)-3-methylquinoxaline | HCID 13670538 | — |
| 反応物 | Methyl 4-bromo-2-pentenoate | HCID 54128087 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl 4-[4-(3-methyl-3-quinoxalinyloxy)phenoxy]pent-2-enoate | HCID 70469256 | — |
反応手順
In a nitrogen atmosphere, add a solution of 5.4 g (0.02 mole) 2-(4-hydroxyphenoxy)-3-methylquinoxaline in 30 cc dimethylformamide to 0.9 g (0.02 mole) 57% sodium hydride in 20 cc dimethylformamide at about 20° C. When the evolution of hydrogen ceases, add 3.9 g (0.02 mole) methyl 4-bromo-2-pentenoate. Heat the reaction mixture at approximately 80° C. until the reaction is complete. Pour the reaction mixture into water and extract with ether. Combine the ethereal extracts and dry over magnesium sulfate. Removal of the ether gives the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04609396 |
|---|
| 出典データセット | uspto-grants-1986_09 |
|---|
| ORD ID | ord-aa9f6b8071fc48d085f88192195dc687 |
|---|
| 出典メモ | uspto-grants-1986_09 |
|---|
