反应详情

温度

80 °C

In a nitrogen atmosphere, add a solution of 5.4 g (0.02 mole) 2-(4-hydroxyphenoxy)-3-methylquinoxaline in 30 cc dimethylformamide to 0.9 g (0.02 mole) 57% sodium hydride in 20 cc dimethylformamide at about 20° C. When the evolution of hydrogen ceases, add 3.9 g (0.02 mole) methyl 4-bromo-2-pentenoate. Heat the reaction mixture at approximately 80° C. until the reaction is complete. Pour the reaction mixture into water and extract with ether. Combine the ethereal extracts and dry over magnesium sulfate. Removal of the ether gives the desired product.

1. extractionextract with ether
2. dry with materialdry over magnesium sulfate
3. customRemoval of the ether