Triethylamine → 3-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol

HRID 64610

反応式

HRID 64610 の反応式
Cl[C:2]1[C:3]([N+:8]([O-:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.C(N(CC)CC)C.[NH2:18][CH2:19][CH:20]([OH:23])[CH2:21][OH:22]>C(O)(C)C>[OH:23][CH:20]([CH2:21][OH:22])[CH2:19][NH:18][C:2]1[C:3]([N+:8]([O-:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 735613-Amino-1,2-propanediolHCID 159142352-Chloro-3-nitropyrazine

生成物 1

HCID 159142393-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a solution of 1.5 g (0.0094 mol) 3 and 1.01 g (0.01 mol) triethylamine in 25 ml isopropanol is added 0.91 g (0.01 mol) 3-amino-1,2-propanediol (10). The reaction mixture becomes reddish and is stirred at room temperature for 16 hours. The solvent is then removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel to afford pure 11 as a yellow solid, m.p. 100°-102°.

後処理

  1. customThe solvent is then removed on the rotary evaporator
  2. customthe residue is purified by flash chromatography on silica gel

出典と根拠

ORDレコード
ord-823de0febb72478ca27925ee6def8ecd
出典データセット
uspto-grants-1986_09
特許番号
US04609659

関連ノート

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