Sodium Methoxide → Sodium 5-(4-isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylate

HRID 646114ノート

反応式

HRID 646114 の反応式
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([C:20]2[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=2)[C:15]([C:30]([OH:32])=[O:31])=[CH:14]3)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].C[O-].[Na+:35]>C1COCC1>[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([C:20]2[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=2)[C:15]([C:30]([O-:32])=[O:31])=[CH:14]3)=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[Na+:35]

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 686968775-(4-Isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylic acid

生成物 1

HCID 68702464Sodium 5-(4-isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylate収率 99%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

5-(4-Isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylic acid (40 mg, 0.095 mmol; see Example 18) was dissolved in dry THF (1 mL) and NaOMe (3.37 M, 28 μL) was added via syringe. After stirring for 30 min at room temperature, the solvents were removed under reduced pressure and the residue dried in vacuo to yield the title compound (42 mg, 99%).

後処理

  1. customthe solvents were removed under reduced pressure
  2. customthe residue dried in vacuo

出典と根拠

ORDレコード
ord-fec5dbf52c024ac3929f3149fc571cb6
出典データセット
uspto-grants-2010_04
特許番号
US07705023B2

反応ノート

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