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Triethylamine → Methyl 6-[(2,3-dihydroxypropyl)amino]-3-nitropyrazine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Amino-1,2-propanediol | HCID 73561 | — |
| 反応物 | Methyl 6-chloro-3-nitropyrazine-2-carboxylate | HCID 15914238 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Methyl 6-[(2,3-dihydroxypropyl)amino]-3-nitropyrazine-2-carboxylate | HCID 15914243 | — |
反応手順
To 1.0 g (0.004 mol) 9 in 15 ml isopropanol is added 0.36 g (0.004 mol) 10 and 0.4 g (0.004 mol) triethylamine at room temperature. The reaction mixture becomes reddish in color and is stirred at room temperature for 16 hours. The solvent is removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel followed by elution with 10% methanol/chloroform. Pure 15 has Rf 0.4 and is obtained as a yellow solid, m.p. 107°-9°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04609659 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-454a61fe3d5d40748003eece1dae88cf |
| 出典メモ | uspto-grants-1986_09 |