反应详情

To 1.0 g (0.004 mol) 9 in 15 ml isopropanol is added 0.36 g (0.004 mol) 10 and 0.4 g (0.004 mol) triethylamine at room temperature. The reaction mixture becomes reddish in color and is stirred at room temperature for 16 hours. The solvent is removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel followed by elution with 10% methanol/chloroform. Pure 15 has Rf 0.4 and is obtained as a yellow solid, m.p. 107°-9°.

1. customThe solvent is removed on the rotary evaporator
2. customthe residue is purified by flash chromatography on silica gel
3. washfollowed by elution with 10% methanol/chloroform
4. customis obtained as a yellow solid, m.p. 107°-9°