Hydrochloric Acid → 1-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine hydrochloride

HRID 646127ノート

反応式

HRID 646127 の反応式
[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([Cl:10])=[O:9])=[CH:4][CH:3]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.Cl>CCOCC.O1CCOCC1>[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[O:9])=[CH:4][CH:3]=1.[ClH:10].[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[O:9])=[CH:4][CH:3]=1

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 45923264HCID 45923264、化合物

生成物 2

HCID 686975001-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine hydrochloride収率 95%HCID 68697501HCID 68697501、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 312751,4-Dioxane溶媒

実験手順

1-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine was prepared in accordance to the procedure described in Example 29(a) from 2-(4-bromophenoxy)-2-methylpropanoyl chloride and 1-methylpiperazine (5.3 mL, 17.5 mmol). This compound (2.37 g, 6.95 mmol) was dissolved in Et2O and HCl in dioxane (4M, 2.26 mL) was added dropwise with stirring. The precipitate was filtered off and dried to yield the sub-title compound (2.5 g, 95%).

後処理

  1. filtrationThe precipitate was filtered off
  2. customdried

出典と根拠

ORDレコード
ord-0b005888c89b4786a135e67675814dcd
出典データセット
uspto-grants-2010_04
特許番号
US07705023B2

反応ノート

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