2-Bromoethyl p-bromophenyl ether → 1-Bromo-4-(ethenyloxy)benzene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10]Br)=[CH:4][CH:3]=1.CC([O-])(C)C.[K+]>C1COCC1.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]=[CH2:10])=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of 1-bromo-4-(2-bromoethoxy)benzene (19.9 g, 100 mmol; see step (a) above) in THF (120 mL) was portion-wise added t-BuOK (14.0 g, 125 mmol) over 10 min at 0° C. After stirring at room temperature for 16 h, the mixture was diluted with water (400 mL) and the product was extracted with light petrol (4×100 mL). The combined organic extracts were washed with brine, dried (Na2SO4), concentrated and distilled under vacuum to yield the sub-title compound (11.5 g, 58%).
後処理
- extractionthe product was extracted with light petrol (4×100 mL)
- washThe combined organic extracts were washed with brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
- distillationdistilled under vacuum
出典と根拠
- ORDレコード
- ord-524fb7489f5d431f97dd0cea24560d0c
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07705023B2
反応ノート
読み込み中…