Sodium Hydroxide → Nalpha-[4(S)-tert-Butoxycarbonylamino-3(S)-hydroxy-6-methylheptyl]-L-leucine

HRID 64643ノート

反応式

HRID 64643 の反応式
C[O:2][C:3](=[O:27])[C@H:4]([CH2:23][CH:24]([CH3:26])[CH3:25])[NH:5][CH2:6][CH2:7][C@H:8]([OH:22])[C@@H:9]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH:11]([CH3:13])[CH3:12].[OH-].[Na+]>O1CCOCC1.O>[C:18]([O:17][C:15]([NH:14][C@@H:9]([CH2:10][CH:11]([CH3:13])[CH3:12])[C@@H:8]([OH:22])[CH2:7][CH2:6][NH:5][C@H:4]([C:3]([OH:27])=[O:2])[CH2:23][CH:24]([CH3:25])[CH3:26])=[O:16])([CH3:21])([CH3:19])[CH3:20]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 13672671Nalpha-[4(S)-tert-Butoxycarbonylamino-3(S)-hydroxy-6-methylheptyl]-L-leucine methyl ester

生成物 1

HCID 13672673Nalpha-[4(S)-tert-Butoxycarbonylamino-3(S)-hydroxy-6-methylheptyl]-L-leucine収率 83%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

2 (700 mg) was dissolved in dioxane (8 ml), diluted with H2O (8 ml) and treated with four portions (2 ml each) of 1N NaOH (aqueous) over a 1.5 hour period. The aqueous dioxane was removed in vacuo and the white solid residue dissolved in H2O (10 ml). The product was precipitated by acidification with 1N HCl and collected by filtration to give 3 as a fine white powder (560 mg, 83% yield) after drying.

後処理

  1. customThe aqueous dioxane was removed in vacuo
  2. dissolutionthe white solid residue dissolved in H2O (10 ml)
  3. customThe product was precipitated by acidification with 1N HCl
  4. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-0360072153b74d609518361aad83fa96
出典データセット
uspto-grants-1986_09
特許番号
US04609641

反応ノート

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