1-Methylimidazole → 1-methyl-3-[2-(4-ethylphenyl)-2-oxoethyl]-1H-imidazolium bromide

HRID 64654

反応式

HRID 64654 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>C(OCC)C>[Br-:1].[CH3:13][NH+:14]1[CH:18]=[CH:17][N:16]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=2)=[O:4])[CH2:15]1

参加物

4

反応物 2

HCID 13901-MethylimidazoleHCID 124019512-Bromo-1-(4-ethylphenyl)ethan-1-one

生成物 1

HCID 703877531-methyl-3-[2-(4-ethylphenyl)-2-oxoethyl]-1H-imidazolium bromide収率 38.2%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 4.41 g (0.019 mol) of 1-bromo-2-(4-ethylphenyl)-2-oxoethane and 1.65 g (0.02 mol) of 1-methylimidazole in 40 ml of diethyl ether was stirred at room temperature for approximately 18 hours. The reaction solvent was decanted, and the residue was washed with diethyl ether and dissolved in a small amount of acetonitrile. The resulting solution was diluted with a small amount of ethyl acetate, whereupon a brown precipitate formed. The solid was collected and recrystallized from acetonitrile/ethyl acetate to provide 2.26 g of 1-methyl-3-[2-(4-ethylphenyl)-2-oxoethyl]-1H-imidazolium bromide as fine yellow brown needles. (38% yield) mp=177°-179° C.

後処理

  1. customThe reaction solvent was decanted
  2. washthe residue was washed with diethyl ether
  3. dissolutiondissolved in a small amount of acetonitrile
  4. additionThe resulting solution was diluted with a small amount of ethyl acetate, whereupon a brown precipitate
  5. customformed
  6. customThe solid was collected
  7. customrecrystallized from acetonitrile/ethyl acetate

出典と根拠

ORDレコード
ord-124ab2184a4f4cee8b6314db4d3d9224
出典データセット
uspto-grants-1986_09
特許番号
US04609670

関連ノート

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