1-Methylimidazole → 1-methyl-3-(1-methyl-2-phenyl-2-oxoethyl)-1H-imidazolium bromide

HRID 64656

反応式

HRID 64656 の反応式
[C:1]1([C:7](=[O:11])[CH:8]([Br:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1>C(OCC)C>[Br-:10].[CH3:12][NH+:13]1[CH:17]=[CH:16][N:15]([CH:8]([CH3:9])[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:11])[CH2:14]1

参加物

4

反応物 2

HCID 13901-MethylimidazoleHCID 164522-Bromopropiophenone

生成物 1

HCID 703877441-methyl-3-(1-methyl-2-phenyl-2-oxoethyl)-1H-imidazolium bromide収率 55%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 8 ml (0.047 mol) of 90% pure 1-phenyl-1-oxo-2-bromopropane and 4.25 g (0.052 mol) of 1-methylimidazole in 100 ml of diethyl ether was stirred at room temperature for approximately 24 hours. The precipitated solid was collected by filtration, washed with diethyl ether and dissolved in methanol. This solution was diluted with diethyl ether and the resulting white solid was collected by filtration. This solid was recrystallized from methanol/diethyl ether to afford 7.65 g of 1-methyl-3-(1-methyl-2-phenyl-2-oxoethyl)-1H-imidazolium bromide as white crystals. (55% yield) mp=167°-170° C.

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with diethyl ether
  3. dissolutiondissolved in methanol
  4. additionThis solution was diluted with diethyl ether
  5. filtrationthe resulting white solid was collected by filtration
  6. customThis solid was recrystallized from methanol/diethyl ether

出典と根拠

ORDレコード
ord-adb1937ba43f4ec58485f7a79e1b4121
出典データセット
uspto-grants-1986_09
特許番号
US04609670

関連ノート

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