1-Methylimidazole → HCID 70387076、化合物

HRID 64658ノート

反応式

HRID 64658 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:6]=1[CH3:12])=[O:4].[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>C(OCC)C>[Br-:1].[CH3:13][NH+:14]1[CH:18]=[CH:17][N:16]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:6]=2[CH3:12])=[O:4])[CH2:15]1

参加物

4

反応物 2

HCID 13901-MethylimidazoleHCID 20634502-Bromo-1-(2,4-dimethylphenyl)ethanone

生成物 1

HCID 70387076HCID 70387076、化合物収率 51%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 4.76 g (0.021 mol) of 1-bromo-2-(2,4-dimethylphenyl)-2-oxoethane and 1.76 g (0.021 mol) of 1-methylimidazole in 50 ml of diethyl ether was stirred at room temperature for approximately 21 hours. The reaction solvent was decanted and the residue was washed with diethyl ether. The residue was recrystallized from acetonitrile/ethyl acetate to afford 3.32 g of the title product as white crystals. (51% yield) mp=179°-181° C.

後処理

  1. customThe reaction solvent was decanted
  2. washthe residue was washed with diethyl ether
  3. customThe residue was recrystallized from acetonitrile/ethyl acetate

出典と根拠

ORDレコード
ord-9b4d12cf9aeb42d6958889fdc6c42afe
出典データセット
uspto-grants-1986_09
特許番号
US04609670

反応ノート

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