1-Methylimidazole → 1-methyl-3-[2-(3-methylphenyl)-2-oxoethyl]-1H-imidazolium bromide

HRID 64659

反応式

HRID 64659 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4].[CH3:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1>C(OCC)C>[Br-:1].[CH3:12][NH+:13]1[CH:17]=[CH:16][N:15]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=2)=[O:4])[CH2:14]1

参加物

4

反応物 2

HCID 13901-MethylimidazoleHCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

生成物 1

HCID 703875941-methyl-3-[2-(3-methylphenyl)-2-oxoethyl]-1H-imidazolium bromide収率 25%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 5.16 g (0.024 mol) of 1-bromo-2-(3-methylphenyl)-2-oxoethane and 2.15 g (0.026 mol) of 1-methylimidazole in approximately 30 ml of diethyl ether was stirred at room temperature for about 19 hours. The reaction solvent was decanted and the resulting brown residue was washed with diethyl ether. The residue was washed with hot acetonitrile and recrystallized twice from acetonitrile/diethyl ether to afford 1.74 g of 1-methyl-3-[2-(3-methylphenyl)-2-oxoethyl]-1H-imidazolium bromide as white needles. (25% yield) mp=185°-187° C.

後処理

  1. customThe reaction solvent was decanted
  2. washthe resulting brown residue was washed with diethyl ether
  3. washThe residue was washed with hot acetonitrile
  4. customrecrystallized twice from acetonitrile/diethyl ether

出典と根拠

ORDレコード
ord-5f078ae1843a466bba893ce12b967e2a
出典データセット
uspto-grants-1986_09
特許番号
US04609670

関連ノート

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