Butanal → 1-But-1-enylpyrrolidine

温度

0 °C

To a dry 500 milliliter (mL) three neck round bottom flask equipped with magnetic stirrer, nitrogen inlet, addition funnel, and thermometer, was charged with pyrrolidine (83.45 mL, 1.0 mmol) and potassium carbonate (34.55 g, 0.25 mol). The mixture was cooled to 0° C. and butanal (30.05 grams (g), 0.42 mol) was added dropwise with stirring under nitrogen at ad rate that maintained the temperature below 15° C. After the addition was complete (˜10 minutes), the cooling bath was taken away and the reaction mixture allowed to warm to room temperature over three hours. The reaction mixture was filtered through a scintered glass filter to remove the solids. The solid was washed thoroughly with ether, and combined with the filtrate, which was concentrated on the rotary evaporator to give the crude 1-but-1-enylpyrrolidine which was purified by vacuum distillation @15 mmHg 65-78° C.; 1H NMR (CDCl3): δ 6.20 (d, 1H), 4.18 (q, 1H), 2.95 (m, 4H), 1.80, (m, 4H), 0.97 (d, 3H).

1. temperaturemaintained the temperature below 15° C
2. additionAfter the addition
3. custom(˜10 minutes)
4. temperatureto warm to room temperature over three hours
5. filtrationThe reaction mixture was filtered through a scintered glass
6. filtrationfilter
7. customto remove the solids
8. washThe solid was washed thoroughly with ether
9. concentrationwas concentrated on the rotary evaporator

ORDレコード

ord-f8a7ef105dde432fb867f800487dc20e

出典データセット

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07705154B2