Sodium Hydroxide → 4-Hydroxycarbazole

HRID 646647

反応式

HRID 646647 の反応式
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[C:4](=[O:14])[CH2:3][CH2:2]1.[OH-].[Na+]>[Ni].O>[OH:14][C:4]1[C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[NH:12][C:13]=2[CH:1]=[CH:2][CH:3]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 9291301,2,3,9-Tetrahydro-4H-carbazol-4-one

生成物 1

HCID 1042514-Hydroxycarbazole

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 962Water溶媒

実験手順

To a reactor containing water (1 L) was added Raney nickel (35 g) followed by 1,2,3,9-tetrahydrocarbazole-4-one (50 g) and sodium hydroxide (15 g). The contents were heated to reflux and maintained for about 20 hours. The catalyst was filtered off and the filtrate was acidified to obtain a solid, which was filtered and dried to obtain the title compound. When necessary, the title compound was further purified by dissolving in 10% sodium hydroxide solution, treating with activated charcoal and precipitation from dilute hydrochloric acid to give off-white to grey crystals of 4-hydroxy carbazole in 50% yield.

後処理

  1. temperatureThe contents were heated
  2. temperatureto reflux
  3. temperaturemaintained for about 20 hours
  4. filtrationThe catalyst was filtered off
  5. customto obtain a solid, which
  6. filtrationwas filtered
  7. customdried

出典と根拠

ORDレコード
ord-8478a4ba9d0a4efe8b2edf31f4d6d925
出典データセット
uspto-grants-2010_04
特許番号
US07705163B2

関連ノート

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