3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole → 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole

HRID 64679ノート

反応式

HRID 64679 の反応式
[O:1]=[C:2]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:12]=1)[CH2:3][CH2:4][CH2:5][C:6]([O:8]CC)=[O:7]>[OH-].[Na+]>[O:1]=[C:2]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:12]=1)[CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7]

参加物

3

反応物 1

HCID 136726963-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole

生成物 1

HCID 136726973-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A mixture of 15.0 of 3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole, 100 ml of 0.5N sodium hydroxide is heated under reflux for 16 hours. The solution is acidified to pH of about 6 with hydrochloric and extracted with methylene chloride. The methylene chloride extract is dried over sodium sulfate and evaporated to dryness to give 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole, melting point 177°-178°.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 16 hours
  3. extractionextracted with methylene chloride
  4. extractionThe methylene chloride extract
  5. dry with materialis dried over sodium sulfate
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-bac6c13fde434d098a681ccd1fde0d81
出典データセット
uspto-grants-1986_09
特許番号
US04609733

反応ノート

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