Sodium Hydroxide → 1-(2-Trimethylsilanyl-ethoxymethyl)-1h-imidazole-4-carboxylate sodium salt
反応式
C[O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH2:10][O:11][CH2:12][CH2:13][Si:14]([CH3:17])([CH3:16])[CH3:15])[CH:9]=1)=[O:4].[OH-].[Na+:19]>CO>[Na+:19].[CH3:15][Si:14]([CH3:17])([CH3:16])[CH2:13][CH2:12][O:11][CH2:10][N:8]1[CH:9]=[C:5]([C:3]([O-:4])=[O:2])[N:6]=[CH:7]1参加物
4
実験手順
To a solution of 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-4-carboxylic acid methyl ester (0.42 g, 1.6 mmol) (as prepared in Example 40, step (a)) in MeOH (3.0 mL) was added 1N NaOH (1.6 mL) and mixture was stirred for 8 h at RT. The reaction was concentrated to give 0.43 g (100%) of the title compound as a white solid. Mass spectrum (ESI, m/z): Calcd. for C10H18N2O3Si, 243.1 (M+H), found 243.1.
後処理
- concentrationThe reaction was concentrated
出典と根拠
- ORDレコード
- ord-32439e82116e49918de0aaef1bbf08eb
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07705042B2
反応ノート
読み込み中…