4-Hydroxybiphenyl → 4-Chloro-(4-biphenylyloxy)-2-butanol

HRID 64693

反応式

HRID 64693 の反応式
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl[CH2:17][CH:18]([OH:22])[CH2:19][CH2:20][Cl:21]>O>[Cl:21][CH2:20][CH2:19][CH:18]([OH:22])[CH2:17][O:13][C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 71034-HydroxybiphenylHCID 14798Sodium HydroxideHCID 170211,4-Dichloro-2-butanol

生成物 1

HCID 131203474-Chloro-(4-biphenylyloxy)-2-butanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
40 °C

実験手順

To a solution of 1 mole (158 g.) of 4-phenylphenol 100 g. of sodium hydroxide and 500 ml. of water was added 1 mole (143.02 g.) of 1,4-dichloro-2-butanol with stirring at 40° C. The resulting mixture was heated at 68° C. in a steam bath for 6 hr., cooled and extracted with 300 ml. of chloroform. The chloroform extract was washed with water to neutrality, dried over sodium sulfate and concentrated to dryness. The solid residue was recrystallized with isopropanol and yielded 180 g. of a white crystalline solid which melted at 123°-124° C.

後処理

  1. temperatureThe resulting mixture was heated at 68° C. in a steam bath for 6 hr
  2. temperature, cooled
  3. extractionextracted with 300 ml
  4. extractionThe chloroform extract
  5. washwas washed with water to neutrality
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated to dryness
  8. customThe solid residue was recrystallized with isopropanol
  9. customyielded 180 g

出典と根拠

ORDレコード
ord-502be600990d42969ee862e5f8dd42f5
出典データセット
uspto-grants-1986_09
特許番号
US04609735

関連ノート

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