Hydrochloric Acid → HCID 20485879、化合物

反応式

[NH2:1][C:2]1[CH:11]=[C:10]([OH:12])[C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[CH:3]=1.[CH2:13]([N:31]([CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH3:61])[C:32](=[O:43])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([S:39](Cl)(=[O:41])=[O:40])[CH:34]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30].Cl>N1C=CC=CC=1>[CH2:44]([N:31]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:32](=[O:43])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([S:39](=[O:40])(=[O:41])[NH:1][C:2]2[CH:11]=[C:10]([OH:12])[C:5]3[N:6]=[C:7]([CH3:9])[O:8][C:4]=3[CH:3]=2)[CH:34]=1)[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH3:61]

参加物

実験手順

To a stirred solution of the 6-amino-4-hydroxy-2-methylbenzoxazole (4.1 g, 0.025 mole) in pyridine (190 ml) was added N,N-dioctadecyl-3-chlorosulfonylbenzamide (Example 5) (18.8 g, 0.026 mole). The mixture was stirred at ambient temperature overnight, then poured into ice water (2 liters) and acidified with hydrochloric acid (200 ml). The resulting precipitate was collected, washed well with water, and dried to yield a tan solid (17.3 g, 81.2 percent). TLC showed the product to be homogeneous.