Triethyl orthoacetate → 2-Methyl-6-nitro-1,3-benzoxazol-4-ol

HRID 647221ノート

反応式

HRID 647221 の反応式
[NH2:1][C:2]1[C:8]([OH:9])=[CH:7][C:6]([N+:10]([O-:12])=[O:11])=[CH:5][C:3]=1[OH:4].[C:13](OCC)(OCC)(OCC)[CH3:14]>C1(C)C=CC=CC=1.C1COCC1>[N+:10]([C:6]1[CH:5]=[C:3]([OH:4])[C:2]2[N:1]=[C:13]([CH3:14])[O:9][C:8]=2[CH:7]=1)([O-:12])=[O:11]

参加物

5

反応物 2

HCID 66221Triethyl orthoacetateHCID 204858732-Amino-5-nitrobenzene-1,3-diol

生成物 1

HCID 204858692-Methyl-6-nitro-1,3-benzoxazol-4-ol収率 39.4%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of the 2-amino-5-nitroresorcinol (2.9 g, 0.017 mole) in toluene (50 ml) and THF (5 ml) was added triethyl orthoacetate (4.1 g, 0.0255 mole). This mixture was heated to reflux for one hour. Upon cooling, the product crystallized out of solution and was collected and dried to yield a tan solid (1.3 g, 39.4 percent). TLC showed the product to be pure.

後処理

  1. temperatureThis mixture was heated
  2. temperatureto reflux for one hour
  3. temperatureUpon cooling
  4. customthe product crystallized out of solution
  5. customwas collected
  6. customdried

出典と根拠

ORDレコード
ord-96063322e09144ec92f8a70e1a7ff405
出典データセット
uspto-grants-1983_10
特許番号
US04407930

反応ノート

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