Pyridine → 4-Nitro-1-indanyl acetate

HRID 647311

反応式

HRID 647311 の反応式
[C:1](Cl)(=[O:3])[CH3:2].N1C=CC=CC=1.[N+:11]([C:14]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:15]=1[CH2:16][CH2:17][CH:18]2[OH:23])([O-:13])=[O:12]>C1(C)C=CC=CC=1>[C:1]([O:23][CH:18]1[C:19]2[C:15](=[C:14]([N+:11]([O-:13])=[O:12])[CH:22]=[CH:21][CH:20]=2)[CH2:16][CH2:17]1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 131024564-Nitro-2,3-dihydro-1H-inden-1-OL

生成物 1

HCID 131024574-Nitro-1-indanyl acetate収率 100.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
5 °C

実験手順

A stirred solution of 40.0 g (0.51 mole) of acetyl chloride and 43.9 g (0.56 mole) of pyridine in 100 mL of toluene was cooled to 5° C., and a solution of 83.0 g (0.46 mole) of 4-nitro-1-indanol in 30 mL of toluene was added dropwise. Upon complete addition, the reaction mixture was stirred at 5° C. for 10 minutes, then was allowed to warm to ambient temperature and was stirred for 16 hours. The reaction mixture was filtered, and the filtrate concentrated under reduced pressure to give 102.7 g of 4-nitro-1-indanyl acetate as an oil.

後処理

  1. additionUpon complete addition
  2. temperatureto warm to ambient temperature
  3. stirringwas stirred for 16 hours
  4. filtrationThe reaction mixture was filtered
  5. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-99595c8a0f2a4a3ab946a8d29d1256b7
出典データセット
uspto-grants-1983_10
特許番号
US04408057

関連ノート

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