Potassium Carbonate → 4-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid

HRID 647375

反応式

HRID 647375 の反応式
[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.Br[CH:21]([CH3:30])[C:22]([O:28][CH3:29])=[CH:23][C:24]([O:26]C)=[O:25].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:18])([F:17])[F:19])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH:21]([CH3:30])[C:22]([O:28][CH3:29])=[CH:23][C:24]([OH:26])=[O:25])=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 129406134-[2-Chloro-4-(trifluoromethyl)phenoxy]phenolHCID 54279858Methyl 4-bromo-3-methoxypent-2-enoate

生成物 1

HCID 538603484-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 4-(2-chloro-4-trifluoromethylphenoxy) phenol (6.9 mmol.), methyl 4-bromo-3-methoxy-2-pentenoate (8.9 mmol.) and potassium carbonate (1.5 equis.) in acetone (15 ml.) is refluxed for 48 hours. After filtration, the filtrate was concentrated and the residue chromatographed on silica gel using 20% ethylacetate/hexane to give the methyl ester of 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid.

後処理

  1. temperatureis refluxed for 48 hours
  2. filtrationAfter filtration
  3. concentrationthe filtrate was concentrated
  4. customthe residue chromatographed on silica gel using 20% ethylacetate/hexane

出典と根拠

ORDレコード
ord-493aa7b9e12743a5bfd74929eaef950c
出典データセット
uspto-grants-1983_10
特許番号
US04408076

関連ノート

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