Hydrochloric Acid → 4-Chloro-2-carboxyphenylacetonitrile

HRID 647418

反応式

HRID 647418 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][O:7][C:8]2=[O:9])=[CH:4][CH:3]=1.[C-:12]#[N:13].[K+].Cl>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:12]#[N:13])=[C:10]([C:8]([OH:7])=[O:9])[CH:11]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 9032Potassium CyanideHCID 71741656-Chloro-3H-isobenzofuran-1-one

生成物 1

HCID 126032044-Chloro-2-carboxyphenylacetonitrile収率 73.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
180 °C

実験手順

A mixture of 6-chlorophthalide (2.0 g) and potassium cyanide (2.0 g) was stirred at a temperature of 180° C. for a period of 4 hours. The solid was cooled, dissolved in water and the solution was acidified with concentrated hydrochloric acid. The dark brown solid was collected, washed with water and dried. The crude solid was dissolved in ethyl acetate, the solution was treated with charcoal, filtered, and the solvent was evaporated to give 4-chloro-2-carboxyphenylacetonitrile (1.70 g) as pale yellow crystals mp 120° C.

後処理

  1. temperatureThe solid was cooled
  2. customThe dark brown solid was collected
  3. washwashed with water
  4. customdried
  5. dissolutionThe crude solid was dissolved in ethyl acetate
  6. additionthe solution was treated with charcoal
  7. filtrationfiltered
  8. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-c2956ed37b054290b05212aa42a30c0c
出典データセット
uspto-grants-1983_10
特許番号
US04409017

関連ノート

読み込み中…