関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3,7-Dichloroisoquinoline | HCID 20484921 | — |
| 反応物 | Sodium 4-methoxyphenolate | HCID 23679016 | — |
| 触媒 | Copper oxide | HCID 14829 | — |
| 生成物 | 7-Chloro-3-(4-methoxyphenoxy)isoquinoline | HCID 13386244 | 45.9% |
反応手順
A mixture of 3,7-dichloroisoquinoline (5.59 g), sodium 4-methoxyphenoxide (4.55 g), potassium carbonate (3.86 g) copper powder (50 mg) and trace of copper oxide were heated at 180° C. for 14 hrs. the mixture was then cooled and extracted with ethyl acetate, which in turn was washed with water, dried (MgSO4) and evaporated to give a crude brown solid. Purification by column chromatography over silica gel gave 7-chloro-3-(4-methoxyphenoxy)isoquinoline (3.70 g) as a tan solid, mp 77° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04409017 |
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| 出典データセット | uspto-grants-1983_10 |
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| ORD ID | ord-8d2791673b6a49dca3f82dd22017e54f |
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| 出典メモ | uspto-grants-1983_10 |
|---|
