反应详情

温度

180 °C

A mixture of 3,7-dichloroisoquinoline (5.59 g), sodium 4-methoxyphenoxide (4.55 g), potassium carbonate (3.86 g) copper powder (50 mg) and trace of copper oxide were heated at 180° C. for 14 hrs. the mixture was then cooled and extracted with ethyl acetate, which in turn was washed with water, dried (MgSO4) and evaporated to give a crude brown solid. Purification by column chromatography over silica gel gave 7-chloro-3-(4-methoxyphenoxy)isoquinoline (3.70 g) as a tan solid, mp 77° C.

1. temperaturethe mixture was then cooled
2. extractionextracted with ethyl acetate, which in turn
3. washwas washed with water
4. dry with materialdried (MgSO4)
5. customevaporated
6. customto give a crude brown solid
7. customPurification by column chromatography over silica gel