4-Chlorophenylacetyl chloride → 2-amino-7-(p-chlorophenylacetyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

HRID 647482ノート

反応式

HRID 647482 の反応式
Br.Br.[NH2:3][C:4]1[CH:5]=[N:6][C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=2[N:14]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](Cl)=[O:24])=[CH:18][CH:17]=1>[OH-].[Na+].O1CCOCC1>[NH2:3][C:4]1[CH:5]=[N:6][C:7]2[CH2:13][CH2:12][N:11]([C:23](=[O:24])[CH2:22][C:19]3[CH:20]=[CH:21][C:16]([Cl:15])=[CH:17][CH:18]=3)[CH2:10][CH2:9][C:8]=2[N:14]=1

参加物

5

反応物 2

HCID 906924-Chlorophenylacetyl chlorideHCID 204363772-amino-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrobromide

生成物 1

HCID 204364612-amino-7-(p-chlorophenylacetyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

試薬・触媒・溶媒 2

HCID 14798Sodium Hydroxide溶媒HCID 312751,4-Dioxane溶媒

実験手順

5.8 gm (17.9 mmols) of 2-amino-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrobromide were dissolved in 50 ml of 2 N sodium hydroxide, and the solution was admixed dropwise with an ice-cooled solution of 7.5 gm of p-chlorophenyl-acetyl chloride in 50 ml of dioxane. The resulting mixture was stirred overnight and then evaporated, and the residue was extracted with chloroform. The chloroform extract was dried and then evaporated, and the residue was triturated with carbon tetrachloride and suction-filtered.

後処理

  1. customevaporated
  2. extractionthe residue was extracted with chloroform
  3. extractionThe chloroform extract
  4. customwas dried
  5. customevaporated
  6. customthe residue was triturated with carbon tetrachloride
  7. filtrationsuction-filtered

出典と根拠

ORDレコード
ord-b600ed6958ab47a9aa77d5440918b0d7
出典データセット
uspto-grants-1983_10
特許番号
US04409220

反応ノート

読み込み中…