Acetyl chloride → N-{[3-(Benzyloxy)pyridin-2-yl]methyl}acetamide

HRID 647502ノート

反応式

HRID 647502 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][CH2:6][C:7]1[C:12]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1.C(N(CC)CC)C>O1CCCC1>[C:1]([NH:5][CH2:6][C:7]1[C:12]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 12074949HCID 12074949、化合物

生成物 1

HCID 13217542N-{[3-(Benzyloxy)pyridin-2-yl]methyl}acetamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Add dropwise with stirring a solution of 3.5 ml acetyl chloride in 50 ml THF (tetrahydrofuran) to a cooled solution of 10 gm of 2-aminomethyl-3-phenylmethoxypyridine and 7.1 ml triethylamine in 125 ml THF. Warm to room temperature and stir an additional hour. Remove triethylamine hydrochloride by filtration and evaporate the filtrate under reduced pressure. Recrystallize the residue from toluene to obtain 2-acetamidomethyl-3-(phenylmethoxy)pyridine, mp 94°-96°.

後処理

  1. additionAdd dropwise
  2. filtrationRemove triethylamine hydrochloride by filtration
  3. customevaporate the filtrate under reduced pressure
  4. customRecrystallize the residue from toluene

出典と根拠

ORDレコード
ord-4d62df5a6a494273b10d5c5f62458d92
出典データセット
uspto-grants-1983_10
特許番号
US04409226

反応ノート

読み込み中…