Acetyl chloride → N-{[3-(2-Phenylethyl)pyridin-2-yl]methyl}acetamide

HRID 647504ノート

反応式

HRID 647504 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][CH2:6][C:7]1[C:12]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1.C(N(CC)CC)C>C1COCC1>[C:1]([NH:5][CH2:6][C:7]1[C:12]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 20485150HCID 20485150、化合物

生成物 1

HCID 20485147N-{[3-(2-Phenylethyl)pyridin-2-yl]methyl}acetamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Add dropwise with stirring a solution of 1.24 gm acetyl chloride in 10 ml THF to a cooled solution of 3.2 gm of 2-aminomethyl-3-(2-phenylethyl)pyridine and 2.3 ml triethylamine in 100 ml THF. Warm the reaction mixture to room temperature and then stir for an additional 0.5 hour. Filter off the triethylamine hydrochloride and evaporate the filtrate under reduced pressure. Chromatograph on silica gel using 40% THF in chloroform to obtain 2-acetamidomethyl-3-(2-phenylethyl)pyridine.

後処理

  1. additionAdd dropwise
  2. filtrationFilter off the triethylamine hydrochloride
  3. customevaporate the filtrate under reduced pressure

出典と根拠

ORDレコード
ord-79e05b060aae480e9679c512c85c0cac
出典データセット
uspto-grants-1983_10
特許番号
US04409226

反応ノート

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