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3-Aminopropionitrile → 3-[N-{2-nitro-5-(2-chloro-4-isopropylsulphonylphenoxy)phenyl}amino]propionitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminopropionitrile | HCID 1647 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Fumarate | HCID 5460307 | — |
| 反応物 | 2-Chloro-4-isopropylsulphonyl-(3,4-dinitrophenoxy)benzene | HCID 20237345 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-[N-{2-nitro-5-(2-chloro-4-isopropylsulphonylphenoxy)phenyl}amino]propionitrile | HCID 20237333 | 70.9% |
反応手順
A solution of 4.0 g of 2-chloro-4-isopropylsulphonyl-(3,4-dinitrophenoxy)benzene and 3.85 g of 3-aminopropionitrile. 0.5 fumarate in 100 ml of acetonitrile, to which 4.1 g of potassium carbonate was added, was refluxed for 6 hours. After evaporation the residue was dissolved in methylenechloride an extracted with water. After washing with water the organic layer was filtered and reduced. Recrystallisation from methanol yielded 3.0 g of the desired product; m.p. 140° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04609753 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-59d1622462e9450283df71a7ce662383 |
| 出典メモ | uspto-grants-1986_09 |