反应详情

A solution of 4.0 g of 2-chloro-4-isopropylsulphonyl-(3,4-dinitrophenoxy)benzene and 3.85 g of 3-aminopropionitrile. 0.5 fumarate in 100 ml of acetonitrile, to which 4.1 g of potassium carbonate was added, was refluxed for 6 hours. After evaporation the residue was dissolved in methylenechloride an extracted with water. After washing with water the organic layer was filtered and reduced. Recrystallisation from methanol yielded 3.0 g of the desired product; m.p. 140° C.

1. temperaturewas refluxed for 6 hours
2. customAfter evaporation the residue
3. dissolutionwas dissolved in methylenechloride
4. extractionan extracted with water
5. washAfter washing with water the organic layer
6. filtrationwas filtered
7. customRecrystallisation from methanol