Hydrochloric Acid → (2-Ethyl-1,6-dioxaspiro[4.5]decan-2-yl)methanol

HRID 647751ノート

反応式

HRID 647751 の反応式
[CH2:1]([C:3]1([O:13][CH2:12]1)[CH2:4][CH2:5][C:6]1[O:11][CH2:10][CH2:9][CH2:8][CH:7]=1)[CH3:2].Cl.C([O:17]CC)C>O1CCCC1>[CH2:1]([C:3]1([CH2:12][OH:17])[CH2:4][CH2:5][C:6]2([CH2:7][CH2:8][CH2:9][CH2:10][O:11]2)[O:13]1)[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 132371796-[2-(2-Ethyloxiran-2-yl)ethyl]-3,4-dihydro-2H-pyran

生成物 1

HCID 13237167(2-Ethyl-1,6-dioxaspiro[4.5]decan-2-yl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To 5.5 g of 6-(3-ethyl-(3,4-epoxybutyl))-3,4-dihydro-2H-pyran was added a solution of 2 ml of 10% hydrochloric acid in 25 ml of tetrahydrofuran. The reaction mixture was stirred under nitrogen for five days and then poured into 150 ml of diethyl ether. The resulting solution was washed twice with 50 ml of saturated sodium bicarbonate solution, and dried, and the solvent was removed under high vacuum to yield 6 g of the desired product as a dark brown oil.

後処理

  1. washThe resulting solution was washed twice with 50 ml of saturated sodium bicarbonate solution
  2. customdried
  3. customthe solvent was removed under high vacuum

出典と根拠

ORDレコード
ord-cadce283ebfd4e47ad7d3e5fa611f4d4
出典データセット
uspto-grants-1983_10
特許番号
US04410354

反応ノート

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