Water → 5-(2-Formyl-3-hydroxyphenoxy)pentanoic acid

HRID 647904

反応式

HRID 647904 の反応式
[CH:1]([C:3]1[C:16]([OH:17])=[C:15](C(O)=O)[CH:14]=[CH:13][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:2].O.[OH-].[Na+]>O1CCOCC1>[CH:1]([C:3]1[C:16]([OH:17])=[CH:15][CH:14]=[CH:13][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:2]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 204843435-(2-Formyl-3-hydroxy-4-carboxyphenoxy)pentanoic acid

生成物 1

HCID 721625-(2-Formyl-3-hydroxyphenoxy)pentanoic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

5-(2-Formyl-3-hydroxy-4-carboxyphenoxy)pentanoic acid (0.2 g, 0.0007 M), acidic alumina (0.1 g), water (10 ml) and dioxane (3 ml) were left at reflux for 4 days. The reaction mixture was cooled, and made alkaline by the addition of sodium hydroxide. The reaction mixture was filtered and the filtrate acidified with concentrated hydrochloric acid. The resulting precipitate was filtered and washed with a little water, then dried in a desiccator over phosphorus pentoxide to give the title compound as a pale-yellow solid, homogeneous on thin layer chromatography.

後処理

  1. temperatureat reflux for 4 days
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe reaction mixture was filtered
  4. filtrationThe resulting precipitate was filtered
  5. washwashed with a little water
  6. dry with materialdried in a desiccator over phosphorus pentoxide

出典と根拠

ORDレコード
ord-83a0171f6a7a4a3a900cc9b5587a8149
出典データセット
uspto-grants-1983_10
特許番号
US04410537

関連ノート

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