Diethyl Ether → Acetate hexane

HRID 64794ノート

反応式

HRID 64794 の反応式
[CH3:1][CH2:2][C:3]([O-:6])([CH3:5])[CH3:4].[Na+].CC[O:10][CH2:11][CH3:12]>C1C=CC=CC=1.O1CCCC1>[C:3]([O-:6])(=[O:10])[CH3:5].[CH3:1][CH2:2][CH2:3][CH2:4][CH2:11][CH3:12]

参加物

5

反応物 2

HCID 3283Diethyl EtherHCID 2733478Sodium 2-methylbutan-2-olate

生成物 1

HCID 22139250Acetate hexane収率 95%

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

0.38 ml of a 1.5M solution of sodium tert-amylate in benzene is added to 126 mg of the mesylate lactone obtained at stage A in 2 ml of anhydrous tetrahydrofuran, at 0° c. The temperature is allowed to rise to 20° C. over 15 minutes. After hydrolysis, extraction is done with ether, then the organic phase is washed with salt water. After chromatographing on a silica column (eluent acetate-hexane 40/60), 73 mg of the cis-cyclopropane lactone expected is obtained. (Yield: 95%).

後処理

  1. customAfter hydrolysis, extraction
  2. washthe organic phase is washed with salt water

出典と根拠

ORDレコード
ord-484cd442d8b3498689e72dba8be8b6cf
出典データセット
uspto-grants-1986_09
特許番号
US04610826

反応ノート

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