Sodium hydride → HCID 20483402、化合物
反応式
[Cl:1][C:2]1[C:7](Cl)=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1.C1(C2[N:20]([CH:21]([CH3:23])[CH3:22])[CH2:19][CH:18]([CH2:24][OH:25])[O:17]2)C=CC=CC=1.[H-].[Na+]>>[Cl:1][C:2]1[C:7]([O:25][CH2:24][CH:18]([OH:17])[CH2:19][NH:20][CH:21]([CH3:23])[CH3:22])=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1参加物
4
実験手順
Analogously to the description in Example 11, 8.2 g (0.05 mol) of 2,3-dichloro-5-methyl-pyrazine, 11 g (0.05 mol) of 2-phenyl-3-isopropyl-5-hydroxymethyl-oxazolidine and 3.4 g of a 50% strength suspension of sodium hydride in paraffin oil give 2-chloro-3-(3'-isopropylamino-2'-hydroxy-propoxy)-5-methyl-pyrazine, melting point 109°-110° C. when crystallised from benzene. The fumarate prepared therefrom by means of fumaric acid crystallises from methanol-ether, melting point 164°-165° C.
出典と根拠
- ORDレコード
- ord-f40ae1cc6c4347acac6a0d9a655d1e8d
- 出典データセット
- uspto-grants-1983_10
- 特許番号
- US04410530
反応ノート
読み込み中…