Methyl iodide → N-methyl,N-(4-chlorophenyl)valine

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH:10]([CH3:12])[CH3:11])=[CH:4][CH:3]=1.[CH3:16]I>>[CH3:16][N:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[C@H:9]([C:13]([OH:15])=[O:14])[CH:10]([CH3:12])[CH3:11]

参加物

反応物 2

HCID 6328Methyl iodide

HCID 13796078N-(p-chlorophenyl)valine

生成物 1

HCID 70536039N-methyl,N-(4-chlorophenyl)valine

実験手順

The α-cyano-m-phenoxybenzyl ester of N-(4-chlorophenyl)valine is reacted with methyl iodide using the procedure of Example 2 to yield the α-cyano-m-phenoxybenzyl ester of N-methyl,N-(4-chlorophenyl)valine, MS m/e 448.1 (M+).

出典と根拠

ORDレコード: ord-7e6c148928314e21a7932bb034c251e1
出典データセット: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04411912

反応ノート

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