化工社化工社 化学情報印刷レポート · 研究参考用
Water → 4-Chloro-2-fluorobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Permanganate | HCID 516875 | — |
| 反応物 | 4-Chloro-2-fluorotoluene | HCID 520630 | — |
| 生成物 | 4-Chloro-2-fluorobenzoic acid | HCID 99152 | — |
反応手順
A mixture of 2-fluoro-4-chlorotoluene (25.05 g), KMnO4 (55.04 g) and water (400 ml) is heated to reflux for about 5 hr. The reaction is then worked up by filtering while hot through Celite and the filtrate is acidified with 2 N HCl. White crystals are filtered off, dissolved in ether and washed with water and brine, dried over sodium sulfate, filtered and evaporated to yield 2-fluoro-4-chlorobenzoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04411912 |
| 出典データセット | uspto-grants-1983_10 |
| ORD ID | ord-fe95aca8fcee4fd08b57c1ccc7c845a0 |
| 出典メモ | uspto-grants-1983_10 |