Acetic Acid → HCID 178511784、化合物
反応式
C(OC([NH:11][C@H:12]([C:19]([N:21]1[CH2:34][CH2:33][CH2:32][C@H:22]1[C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:24])=[O:20])[CH2:13][C:14]1[N:18]=[CH:17][NH:16][CH:15]=1)=O)C1C=CC=CC=1.Br.C(O)(=O)C>CCOCC>[NH2:11][C@H:12]([C:19]([N:21]1[CH2:34][CH2:33][CH2:32][C@H:22]1[C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:24])=[O:20])[CH2:13][C:14]1[N:18]=[CH:17][NH:16][CH:15]=1参加物
5
実験手順
To 1.79 g of compound (95) was added 19 ml of 25% hydrobromic acid--acetic acid cooled in an ice bath followed by stirring one hour at room temperature. The reaction mixture was added to 190 ml of desiccator ether and precipitates thus formed were quickly collected by filtration and dried overnight in a desiccator containing potassium hydroxide to provide 2.05 g of L-histidyl-N-phenyl-L-prolinamide.2-hydrobromide (96).