Dimethyl Sulfoxide → 1-Methyl-3-(4-nitrophenyl)imidazolidin-2-one

HRID 648481ノート

反応式

HRID 648481 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][NH:12][C:11]2=[O:15])=[CH:6][CH:5]=1)([O-:3])=[O:2].IC.[OH-].[K+].[CH3:20]S(C)=O>O>[CH3:20][N:12]1[CH2:13][CH2:14][N:10]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)[C:11]1=[O:15]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 6328Methyl iodide2 回HCID 14797Potassium Hydroxide2 回HCID 3186721-(4-Nitrophenyl)imidazolidin-2-one

生成物 1

HCID 137323581-Methyl-3-(4-nitrophenyl)imidazolidin-2-one収率 74%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 21 parts of 1-(4-nitrophenyl)-2-imidazolidinone, 16 parts of iodomethane, 10 parts of potassium hydroxide and 200 parts of dimethyl sulfoxide was stirred for 3 hours at room temperature. Another portion of 16 parts of iodomethane and 10 parts of potassium hydroxide were added. Stirring was continued overnight. 300 Parts of water were added to the reaction mixture and the whole was stirred. The precipitated product was filtered off and crystallized from 4-methyl-2-pentanone, yielding 16.5 parts (74%) of 1-methyl-3-(4-nitrophenyl)-2-imidazolidinone; mp. 214.1°-215.5° C. (7).

後処理

  1. stirringStirring
  2. waitwas continued overnight
  3. stirringthe whole was stirred
  4. filtrationThe precipitated product was filtered off
  5. customcrystallized from 4-methyl-2-pentanone

出典と根拠

ORDレコード
ord-ffc80d2c462c44d5a8bb8de8c0b71fc4
出典データセット
uspto-grants-1988_04
特許番号
US04735942

反応ノート

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