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4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride → 4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoyl chloride hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride | HCID 13825035 | — |
| 溶媒 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | 4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoyl chloride hydrochloride | HCID 13825037 | 200.4% |
反応手順
A suspension of 4-[[3-ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride (2.51 g) in thionyl chloride (25 ml) was stirred under reflux for 4 hours and concentrated to dryness in vacuo to give 4-[[3-ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoyl chloride hydrochloride (2.62 g) as yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04735952 |
| 出典データセット | uspto-grants-1988_04 |
| ORD ID | ord-c8306702bfee473bab7017d92f61a2b7 |
| 出典メモ | uspto-grants-1988_04 |