Water → 2-Chloro-6-nitro-3-pyrrolidinobenzonitrile

HRID 64861ノート

反応式

HRID 64861 の反応式
[Cl:1][C:2]1[C:9](Cl)=[CH:8][CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:3]=1[C:4]#[N:5].[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.O>CN(C)C=O>[Cl:1][C:2]1[C:9]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:8][CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:3]=1[C:4]#[N:5]

参加物

5

反応物 3

HCID 962WaterHCID 31268PyrrolidineHCID 27360202,3-Dichloro-6-nitrobenzonitrile

生成物 1

HCID 134992682-Chloro-6-nitro-3-pyrrolidinobenzonitrile収率 88.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

13.0 g of 2,3-dichloro-6-nitrobenzonitrile was dissolved in 50 ml of dimethylformamide, and 11.0 g of pyrrolidine was added to the solution, followed by stirring while externally cooling because of heat generation. After continuing the stirring for 30 minutes, the reaction mixture was poured into water. The precipitate thus formed was filtered, washed with water and then with methanol to obtain 13.3 g of 2-chloro-6-nitro-3-pyrrolidinobenzonitrile (melting point: 170°-173° C.).

後処理

  1. temperaturewhile externally cooling because of heat generation
  2. customstirring for 30 minutes
  3. customThe precipitate thus formed
  4. filtrationwas filtered
  5. washwashed with water

出典と根拠

ORDレコード
ord-25bd0f96e9344708b7d10565fea58a47
出典データセット
uspto-grants-1986_09
特許番号
US04610987

反応ノート

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