4-Phenylbutyric Acid → Cyclohexanebutanoic acid

HRID 648623

反応式

HRID 648623 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>C(O)(=O)C.[Pt]=O>[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 47754-Phenylbutyric AcidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 75200Cyclohexanebutanoic acid収率 77%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 176Acetic Acid溶媒

実験手順

4-Phenylbutanoic acid prepared as described in Example 56, Part A was dissolved in glacial acetic acid (25 ml). Platinum oxide (0.1 g) was added and the solution was hydrogenated in the Paar shaker at up to 55 p.s.i. until hydrogen uptake ceased (6.5 hours). The catalyst was removed by filtration and the acetic acid was removed in vacuo. The product crystallized and was recrystallized from Et2O (20 ml) to give title compound (1.18 g, 77%), m.p. 85°-88° C.

後処理

  1. custom(6.5 hours)
  2. customThe catalyst was removed by filtration
  3. customthe acetic acid was removed in vacuo
  4. customThe product crystallized
  5. customwas recrystallized from Et2O (20 ml)

出典と根拠

ORDレコード
ord-ae9037d73c6549bfa34638ad5ccece91
出典データセット
uspto-grants-1988_04
特許番号
US04735962

関連ノート

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