HCID 20145212、化合物 → HCID 20145176、化合物

HRID 648657ノート

反応式

HRID 648657 の反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]([N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[C:6]([CH:8]([CH:12]([C:22]([NH2:24])=[O:23])[C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH3:11])[CH:7]=1.[H][H]>C(O)C.[Pd]>[N:25]1([C:5]2[CH:4]=[CH:3][CH:2]=[CH:7][C:6]=2[CH:8]([CH:12]([C:22]([NH2:24])=[O:23])[C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH3:11])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1

参加物

5

反応物 2

HCID 20145212HCID 20145212、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 20145176HCID 20145176、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

One gram (2.33 m mol) of 4-[(1-(5-chloro-2-piperidinophenyl)-1-butyl)-aminocarbonylmethyl]-benzoic acid in 40 ml of absolute ethanol was hydrogenated on 0.5 gm of 10% palladium/charcoal at 50° C. and under 5 bar of hydrogen. After two hours, the catalyst was filtered off over kieselguhr, and the filtrate was concentrated by evaporation in vacuo. The evaporation residue was distributed at pH 6 between water and ethyl acetate. The organic extract was washed with water, dried, filtered, and evaporated in vacuo.

後処理

  1. filtrationthe catalyst was filtered off over kieselguhr
  2. concentrationthe filtrate was concentrated by evaporation in vacuo
  3. extractionThe organic extract
  4. washwas washed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-520e625b59054f978c9441a6f29369ca
出典データセット
uspto-grants-1988_04
特許番号
US04735959

反応ノート

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