p-Anisoyl chloride → HCID 13371227、化合物

HRID 64866

反応式

HRID 64866 の反応式
[N:1]1([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:16]([Cl:26])(=[O:25])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1>C(Cl)Cl.C(O)(C)C>[ClH:26].[CH3:24][O:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]([N:4]2[CH2:3][CH2:2][N:1]([CH2:7][C:8]([N:10]3[CH2:11][CH2:12][O:13][CH2:14][CH2:15]3)=[O:9])[CH2:6][CH2:5]2)=[O:25])=[CH:18][CH:19]=1

参加物

5

反応物 2

HCID 7477p-Anisoyl chlorideHCID 1006221-(Morpholinocarbonylmethyl)piperazine

生成物 1

HCID 13371227HCID 13371227、化合物

試薬・触媒・溶媒 2

HCID 3776Isopropanol溶媒HCID 6344Dichloromethane溶媒

実験手順

10.25 g of piperazin-1-yl-acetic acid morpholide are cooled to 0° C. in 20 ml of methylene chloride. 8.75 g of anisoyl chloride are added dropwise in the course of 15 minutes. After the mixture has been subsequently stirred for 4 hours, it is diluted with isopropanol, whereupon the colourless product precipitates. It is filtered off with suction and dried.

後処理

  1. customprecipitates
  2. filtrationIt is filtered off with suction
  3. customdried

出典と根拠

ORDレコード
ord-21ca3ae338254865a0d42275bcf052d1
出典データセット
uspto-grants-1986_09
特許番号
US04610984

関連ノート

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