Hydrogen Bromide → 106487-32-5
反応式
C[O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2.[BrH:19]>>[BrH:19].[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2参加物
3
実験手順
A mixture of 1.5 g of the product of Example 1 in 15 ml of concentrated hydrobromic acid (d=1.49) was refluxed for 2 hours 30 minutes under an inert atmosphere and after evaporating to dryness under reduced pressure, taking up the residue with benzene, concentrating to dryness, adding 2 ml of ethanol, filtering the crystals obtained, drying under reduced pressure, and purifying by crystallization from ethanol, 1.4 g of 1,3-dihydro-7-hydroxy-4-(3-piperidinyl)-2H-indol-2-one hydrobromide melting at 190° C., then 250° C. were obtained.
後処理
- temperaturewas refluxed for 2 hours 30 minutes under an inert atmosphere
- customafter evaporating to dryness under reduced pressure
- concentrationconcentrating to dryness
- additionadding 2 ml of ethanol
- filtrationfiltering the crystals
- customobtained