Phosphorus oxychloride → 2-Chloro-4-(4-fluorobenzoyl)-pyridine

HRID 648717

反応式

HRID 648717 の反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][N+:11]([O-])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:19]>>[Cl:19][C:12]1[CH:13]=[C:8]([C:6](=[O:7])[C:5]2[CH:15]=[CH:16][C:2]([F:1])=[CH:3][CH:4]=2)[CH:9]=[CH:10][N:11]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 541432034-(4-fluorobenzoyl)-pyridine N-oxide

生成物 1

HCID 201457102-Chloro-4-(4-fluorobenzoyl)-pyridine

実験手順

0.88 g 4-(4-fluorobenzoyl)-pyridine N-oxide and 50 ml POCl3 are refluxed for 2 hrs. Excess POCl3 is distilled at normal pressure. The crude is treated with slightly alkaline cold water and then extracted with methylene chloride. Working as usual affords 0.80 g of title product, identical with that obtained by the Friedel-Crafts process (see Ex. 3d).

後処理

  1. distillationExcess POCl3 is distilled at normal pressure
  2. additionThe crude is treated with slightly alkaline cold water
  3. extractionextracted with methylene chloride

出典と根拠

ORDレコード
ord-297ae98322534e3db5a0a6253499a89f
出典データセット
uspto-grants-1988_04
特許番号
US04736037

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