Hydrochloric Acid → Octyl 4-formylbenzoate

HRID 648873ノート

反応式

HRID 648873 の反応式
[C:1](Cl)(=[O:10])[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[CH2:12]([OH:20])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].Cl>C1(C)C=CC=CC=1.N1C=CC=CC=1>[CH2:12]([O:20][C:1]([C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)=[O:10])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 9571-OctanolHCID 124246204-Formylbenzoyl chloride

生成物 1

HCID 13404982Octyl 4-formylbenzoate収率 70.7%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 1140Toluene溶媒2 回

反応条件

温度
60 °C

実験手順

Next, a solution of the above terephthalaldehydic acid chloride (20 g) dissolved in toluene (100 ml) was dropwise added to a solution of 1-octanol (20 g) dissolved in pyridine (150 ml), followed by heating the mixture on a water bath at 60° C. with stirring, allowing to stand overnight, thereafter adding toluene (500 ml), adding 6N hydrochloric acid, separating the liquid layer, washing with an aqueous solution of 2N NaOH, washing with water, drying, distilling off toluene, and further distilling under reduced pressure to obtain p-octyloxycarbonylbenzaldehyde (166°~167° C./4 mmHg) (22 g).

後処理

  1. customseparating the liquid layer
  2. washwashing with an aqueous solution of 2N NaOH
  3. washwashing with water
  4. customdrying
  5. distillationdistilling off toluene
  6. distillationfurther distilling under reduced pressure

出典と根拠

ORDレコード
ord-6f876f40763e4b7d92bfda9337b5d5e7
出典データセット
uspto-grants-1988_04
特許番号
US04737313

反応ノート

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