Acetic Acid → HCID 178468982、化合物

HRID 648901

反応式

HRID 648901 の反応式
C(C1C=C[C:9]([NH:12][NH:13][C:14]([NH2:16])=[S:15])=CC=1)(OCC)=O.[CH:17]([O-:22])([O-])[O:18][CH2:19][CH3:20].C(O)(=O)C.[CH3:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]>>[C:17]([C:29]1[CH:28]=[CH:27][C:32]([N:16]2[CH:9]=[N:12][N:13]=[C:14]2[SH:15])=[CH:31][CH:30]=1)([O:18][CH2:19][CH3:20])=[O:22]

参加物

5

反応物 4

HCID 176Acetic AcidHCID 8058HexaneHCID 197457524-EthoxycarbonylphenylthiosemicarbazideHCID 53630039Ethylorthoformate

生成物 1

HCID 178468982HCID 178468982、化合物収率 75.9%

反応条件

温度
120 °C

実験手順

A mixture of 13.2 g of (4-carboethoxyphenyl)thiosemicarbazide, 52.8 ml of ethyl orthoformate, and 3.3 g of acetic acid was stirred for 2 hours at 120° C. After cooling the mixture to room temperature, hexane was added to the mixture and crystals thus formed were collected by filtration and recrystallized from ethanol to provide 10.4 g of 1-(4-carboethoxyphenyl)-2-mercapto-1,3,4-triazole. The yield was 75.9% and the melting point was 194°-196° C.

後処理

  1. temperatureAfter cooling the mixture to room temperature
  2. customthus formed
  3. filtrationwere collected by filtration
  4. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-17ebcef140f64fa1a98937d7285ff0b4
出典データセット
uspto-grants-1988_04
特許番号
US04737452

関連ノート

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