Tetrahydrofuran → HCID 20144491、化合物

HRID 649017ノート

反応式

HRID 649017 の反応式
Br[C:2](Br)=[CH:3][C:4]1[C:5]2[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:6]=2[S:7][CH:8]=1.O1CCCC1.C([Li])CCC.C([O-])(O)=O.[Na+]>CCCCCC>[C:3]([C:4]1[C:5]2[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:6]=2[S:7][CH:8]=1)#[CH:2]

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 20144461HCID 20144461、化合物HCID 178418339Butyllithium

生成物 1

HCID 20144491HCID 20144491、化合物

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

0.6 g of 3-(dibromovinyl)-7-methylbenzo[b]thiophene are dissolved in abs. tetrahydrofuran and 3.38 ml of a 15% solution of n-butyllithium in n-hexane are added dropwise under inert gas and at -78°. Stirring is continued for one hour at -78° and the mixture subsequently warmed to room temperature, poured into saturated aq. NaHCO3 and extracted with ether. The organic phase is washed, dried, concentrated and directly further reacted.

後処理

  1. extractionextracted with ether
  2. washThe organic phase is washed
  3. customdried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-0eb66eba03164279873631165f2d56a4
出典データセット
uspto-grants-1988_04
特許番号
US04737516

反応ノート

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