Isopropylamine → N-isopropyl-N'-(7-chloro-2-methylimidazo[2,1-a]isoquinolin-3-yl)formamidine dihydrochloride
反応式
[CH:1]([NH2:4])([CH3:3])[CH3:2].C(N[CH:8]=[N:9][C:10]1[N:14]2[CH:15]=[CH:16][C:17]3[C:22]([C:13]2=[N:12][C:11]=1[CH3:24])=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])#N>O>[ClH:23].[ClH:23].[CH:1]([NH:4][CH:8]=[N:9][C:10]1[N:14]2[CH:15]=[CH:16][C:17]3[C:22]([C:13]2=[N:12][C:11]=1[CH3:24])=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])([CH3:3])[CH3:2]参加物
4
実験手順
Isopropylamine (2 ml) was added to a suspension of N-cyano-N'-(7-chloro-2-methylimidazo[2,1-a]isoquinolin-3-yl)formamidine (0.95 g) in water (1.5 ml) and the mixture was stirred at room temperature for 30 minutes. The resulting precipitate was collected by filtration, washed with water and dissolved in ethanol. To the solution was added a saturated solution of hydrogen chloride in ethanol and the mixture was evaporated in vacuo. The residual solid was washed successively with a mixture of diethyl ether and ethanol and isopropanol and then dried in a desiccator to give N-isopropyl-N'-(7-chloro-2-methylimidazo[2,1-a]isoquinolin-3-yl)formamidine dihydrochloride (0.73 g).